Full factorial and fractional factorial designs are widely used to explore the relationship between the response and experimental factors of interest. The primary focus of this course is to introduce systematic methods and practical techniques for planning and analyzing multifactorial experiments. To implement these useful approaches, R scripts will be provided and demonstrated in class. In addition, some recent research topics will also be covered. After successfully completing this course, students will be able to design multifactorial experiments to address real-world research issues and interpret the analysis results correctly.